Backed by
AI-DRIVEN
MOLECULAR
DISCOVERY
Identify and design molecules with novel mode of action for next-gen crop protection.
Bindbridge uses AI to discover and design targeted protein degraders that selectively bind in plants or pests, enabling the development of safer, more effective herbicides, fungicides, and insecticides.
SCIENCE
A Novel Class of Ag Chemistry
FASTER & LOWER COST DISCOVERY
Our computational approach results in faster and cheaper R&D with higher success rates to commercialisation than conventional approaches.
SCALABLE DISCOVERY METHOD
The platform can be used for solutions across herbicides, insecticides, fungicides, and sprayable plant traits.
PRECISE & SELECTIVE TARGETS
Targeted protein degradation as a novel class of Ag chemistry minimises off-target effects by selectively binding organism-specific proteins and degraders.
FIT EXISTING AG SUPPLY CHAINS
Small-molecule chemistry fits existing ag supply chains from manufacturing to use.
Build world leading AI for targeted protein degradation in plants
Leveraging the plant's natural control system for a new mode of action crop protection agents.
Proximity inducers (incl. Molecular Glues) bind a target protein to a protein degrader — the target protein gets broken down, and produces a response in the plant or pest.
PRODUCT
Computational discovery of targeted protein degraders for agriculture.
BRIDGE
Chemistry-First Generation of Targeted Protein Degraders
From molecule to field
TARGETSELECTION
Selection of target protein relevant to weed or crop disease
CANDIDATEGENERATION
AI-driven generation of small molecule candidates
VIRTUALSCREENING
Screening of top performing degrader candidates
COMPOUNDVALIDATION
Assessment of novel
compounds in the field
End-to-end screening pipeline
The BRIDGE platform integrates directly into a multi-stage physics-based screening pipeline. Structure validation identifies overall performing candidates.
BRIDGE
Generates novel targeted protein degraders from molecular building blocks, constrained to synthetically accessible chemistry.
Fast
filtering
Computationally efficient docking tools to reject the majority of MGs.
Molecular
dynamics
Molecular Dynamics simulations to assess stability in the binding pockets.
Free
energy
prediction
High-fidelity free energy calculations, providing our most accurate binding strength predictions at the final stage of screening.
The BRIDGE platform turns compound discovery for targeted protein degradation into a scalable, repeatable, and verifiable process.